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COLLOIDAL SILVER
Deep Dive Into the World of Nanotherapeutics!
Join us in exploring the latest nanoparticle science and the production of sovereign nanotherapeutics. We will uncover the basics of Colloidal Silver, how we use it, and why it is effective. Take a deep dive into the complex science of producing safe and bioavailable formulations.
Topics
Colloidal silver is a natural, non-toxic, highly effective antiseptic, antifungal, antibacterial, and antibiotic. [1][2][3] Stable silver nanoparticles (AgNPs) are uniquely efficacious against a wide range of bacteria, including multidrug-resistant strains, by disrupting microbial membranes and proteins. [4] They are also active against viruses and fungi, including Candida species. [5] Aloe-encapsulated silver nanoparticles (AgNPs@AV) enhance bioavailability and reduce toxicity, providing a robust therapeutic safety profile. [6][7]
Colloidal Silver is a virtually tasteless “yellow” liquid that can be applied topically, nebulized, or taken internally [1][8]. It is soothing on burns and scrapes and fast-acting for respiratory, sinus, eye, skin and other infections [10][11].
Simply put, apply it where you need it, worry-free.
Colloidal silver exhibits broad-spectrum antibacterial, antifungal, antiviral, and anti-inflammatory properties [12][12B][13]. Its effectiveness spans Gram-positive and Gram-negative bacteria, including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) [14a][14b]. Studies confirm its activity against viruses like influenza, herpes simplex virus (HSV), and HIV [15a][15b][15c], as well as against fungal pathogens, particularly Candida species [16][17]. AgNPs also efficiently disrupt biofilms, a significant factor in chronic infections [12][18].
AgNPs accelerate wound healing by promoting collagen synthesis and reducing infection, with additional roles in stimulating angiogenesis (formation of new blood vessels) [19a][19b]. It is used for cuts, scrapes and burns and for the treatment of acne, psoriasis, eczema, and other skin conditions.[19c]. Silver nanoparticles not only kill unwanted skin bacteria but also reduce inflammation, offering a gentle alternative to harsh chemical treatments.
Silver nanoparticles (AgNPs) have demonstrated the ability to influence stem cell behavior, promoting differentiation and activity that aids in the regeneration of damaged tissues including skin, muscles, and nerves. Studies show that AgNPs can enhance the differentiation potential of mesenchymal stem cells, facilitating the repair of tissue damage [26]. Additionally, the nanoscale properties of silver particles support cellular proliferation and angiogenesis, critical for effective tissue regeneration [27].
Recent research highlights the ability of AgNPs to aid in the regeneration of specific tissues, such as corneal limbal stem cells, offering promising applications in restoring vision for individuals with corneal injuries [28][28B]. Another study explores induced dedifferentiation, where silver facilitates the reprogramming of mature cells into a more primitive state, potentially paving the way for novel regenerative therapies [28C].
Colloidal silver is an effective complement to antibiotics and, in some cases, an alternative, especially when treating multi-drug resistant (MDR) pathogens [29][30]. Studies demonstrate that silver nanoparticles enhance the efficacy of conventional antibiotics against MDR bacteria, offering a synergistic effect [29]. “Silver nanoparticles exhibit superior performance in disrupting biofilms, a significant barrier in treating chronic infections caused by multidrug-resistant bacteria” [12A][31]. As concerns about antibiotic resistance grow, exploring and integrating such viable solutions is more important than ever.
Colloidal Silver is a modern remedy with remarkable potential for non-toxic relief of various health issues [37]. Backed by centuries of historical use [38] and bolstered by contemporary scientific studies [39], it is gaining recognition for its antimicrobial [1][40], anti-inflammatory [40b], and regenerative properties [11]. This versatile therapeutic stands out for its ability to target a broad spectrum of pathogens, support immune modulation, and promote tissue healing—all while maintaining an excellent safety profile when used correctly [42].
In this section, we will explore what colloidal silver is, how it works, the scientific evidence supporting its effectiveness, its safety considerations, and address some common misconceptions surrounding its use.
Colloidal Silver is a modern nanotechnology-based therapeutic comprised of silver nanoparticles (AgNPs) with unique antimicrobial [4][40], anti-inflammatory [40B], and tissue-regenerative properties [11]. These nanoparticles release silver ions that bind to bacterial cell walls, disrupting metabolic processes [39][3] and producing free radicals that eradicate harmful microbes [3][6]. Additionally, AgNPs suppress inflammatory responses by modulating cytokine production, aiding in the reduction of swelling and pain [40B][42].
Beyond their antimicrobial actions, silver nanoparticles support tissue regeneration by promoting collagen synthesis and angiogenesis (the formation of new blood vessels.) This dual capacity to inhibit infection while accelerating tissue repair makes colloidal silver an invaluable therapeutic for wound healing and broader regenerative applications [10][44].
Encapsulation technologies, such as aloe vera-stabilized silver nanoparticles, further enhance bioavailability, extend therapeutic interactions, and minimize potential risks [7][13]. Aloe vera’s phytochemicals create a natural protective layer around silver nanoparticles, preventing aggregation and enhancing cellular compatibility [7][8][13][41]. These advancements establish colloidal silver as a next-generation therapeutic platform for broad-spectrum applications.
Colloidal Silver has a gentle profile, and its effectiveness is well-established [37][48]. Modern production techniques and growing scientific knowledge have significantly enhanced its therapeutic potential, increasing potency while minimizing toxicity. Among these advancements, plant encapsulated colloidal silver represents a breakthrough in enhancing potency and minimizing toxicity, with protective encapsulation layers ensuring targeted delivery, extended bioavailability, and reduced side effects [13][7][41][46][47]. Renewed public interest and the continued amassing of rigorous scientific research highlight silver’s enduring and efficacious nature as a next-generation therapeutic [37].
Properly produced colloidal silver is one of the most effective antibacterial agents known, with demonstrated activity against all tested bacterial strains, including multidrug-resistant pathogens [15A][34]. Its unique ability to disrupt bacterial structures without harming mammalian cells makes it a groundbreaking, non-toxic alternative to conventional antibiotics [6][34].
Colloidal silver’s efficacy has been substantiated through both in vivo studies and extensive real-world applications [49]. Historically, silver treatments have been employed to aid in healing infections and wounds, with its use dating back to ancient civilizations [50]. In modern medicine, silver treatments, such as silver sulfadiazine, are a standard in burn care to prevent infections [51]. Additionally, silver nanoparticles have been incorporated into wound dressings and medical devices, leveraging their antimicrobial properties while maintaining biocompatibility [52]. Studies have further highlighted silver’s antimicrobial efficacy in complex wound environments, showcasing its versatility in advanced medical applications [54]. Silver’s antimicrobial properties also make it an effective agent for water purification, with real-world applications including portable filtration systems used in military and emergency settings [53].
Critical nanoparticle characteristics such as particle size uniformity, stability, surface area, encapsulation quality, and the use of stabilizing agents play a vital role in determining safety and effectiveness. Properly characterized silver nanoparticles (AgNPs) exhibit selective action against harmful pathogens while sparing beneficial microorganisms, enhancing their therapeutic potential [15A][19A][47]. Encapsulation, reduction, and stabilization improve bioavailability and minimize cytotoxicity, making them safer and more effective for medical applications [40B][57][56].
Good Electricity employs a novel production process utilizing gentle large-plate electrolysis and in-situ particle processing. This technique simultaneously reduces, stabilizes, and encapsulates silver nanoparticles within aloe vera particles, creating AgNP@Av with unparalleled bioavailability. Aloe vera’s phytochemicals form a natural encapsulation barrier that enhances stability, prevents aggregation, and ensures the biocompatibility of silver nanoparticles [47][38][55]. In other words, this method forms a natural barrier, ensuring silver interacts with the body from the biocompatible platform of aloe vera cells [13].
This innovative approach aligns with findings from green synthesis studies that highlight the importance of plant-based reducing agents like aloe vera in creating stable and safe formulations. For example, Box-Behnken optimization and the use of Moringa oleifera leaf extract demonstrate how phytochemical-rich sources ensure uniform particle size and biocompatibility, reinforcing their therapeutic potential [55][56][58]. These methods not only enhance stability but also reduce cytotoxicity, supporting the development of next-generation nanotherapeutics [57][59][60].
Silver in various forms have been a cornerstone in emergency medicine due to its exceptional antimicrobial properties. It is critical in managing infections in burn units, emergency rooms, and surgical settings. Silver coatings on surgical instruments and advanced wound dressings are essential for reducing infection risks [47][19B][11A]. Additionally, silver plays a vital role in water purification systems for military and disaster relief scenarios, where its potent bactericidal effects ensure safe drinking water [31][55].
Colloidal Silver, specifically, is gaining widespread adoption in proactive self-care. Its potent antimicrobial and anti-inflammatory properties make it ideal for addressing sinus, respiratory, and post-injury infections, including burns, cuts, and surgical wounds [57][19A][60]. Research highlights its ability to inhibit biofilms, which are critical barriers in chronic infections [12A][30].
Colloidal Silver is increasingly used in cutting-edge medical applications:
Good Electricity emerged from over five years of research into the science of nanoparticle therapeutics, focused on creating safe, effective, and bioavailable formulations. This journey involved studying hundreds of foundational and modern research papers that revealed both the immense potential and challenges of colloidal silver. Over the last decade, advancements in nanoparticle synthesis and encapsulation have transformed therapeutic applications, inspiring our approach [11A][56].
Through this research, it became clear that not all colloidal silver products are created equal. While high-quality silver nanoparticles demonstrate exceptional antimicrobial and anti-inflammatory properties with proven safety at medical doses, improperly produced or ionic silver solutions can carry risks [47][19A]. Regulatory agencies, including the FDA and SCENIHR, acknowledge the safety and effectiveness of high-quality colloidal silver when manufactured with precision, reinforcing the importance of proper production methods [7].
Good Electricity’s innovation lies in combining modern advancements with traditional principles, identifying that controlled reduction, stabilization, and encapsulation are key to producing nanoparticles that are both effective and biocompatible. This led to the discovery of aloe vera as an ideal partner in nanoparticle formulation. Unlike other plant-based agents, aloe vera’s natural chemistry is uniquely synergistic—it actively reduces, stabilizes, and encapsulates silver nanoparticles in a way that feels almost intuitive, particularly at lower temperatures [57][60]. These conditions result in a smoother, more efficient production process that minimizes energy use. Beyond its functional benefits, aloe vera also offers therapeutic appeal, being a well-recognized and trusted ingredient that aligns with expectations for safe, natural therapeutics.
This endeavor represents more than product development—it reflects a commitment to advancing nanotherapeutics while carefully navigating the often confusing space of “colloidal silver.” We aim to create scientifically sound formulations and share evidence-based insights to help individuals make informed decisions. Good Electricity is dedicated to innovation, safety, and transparency, empowering consumers with knowledge in this evolving field.
Nanoscale products are defined by manufacturing practices involving materials with at least one physical dimension measuring less than 100 nanometers [12B]. Materials exhibit remarkable properties at this scale, often described as “supernatural,” as they operate under physical laws that fundamentally differ from those governing larger-scale materials [37]. Variables such as size, shape, charge, density, and proximity/dispersion significantly influence these properties [23B].
For example, smaller particles of the same material are inherently more reactive due to their increased surface area-to-volume ratio. This phenomenon manifests differently across applications: in semiconductors, it results in lower power requirements for electrical conduction [37], while in biochemistry, it allows for reduced dosages of active ingredients to achieve the same therapeutic effects, thereby minimizing toxicity and enhancing potency [15A][12B].
Nano-sized structures in butterfly wings enable their amazing hydrophobic and colour scattering properties.
For the most apparent showcases of what only nano-sized materials can do, you just have to think of some of nature’s superpowers [61], like the strength of spider silk [61], the iridescence of butterfly wings [62], or the grippyness of lizard feet [63]. These natural “superpowers” inspire cutting-edge advancements in material science and therapeutics, allowing us to emulate nature’s elegant solutions on the nanoscale [12B].
Research and production at the nano level are at the forefront of the modern industrial revolution [30], influencing diverse fields such as computing, printing, communication, display technologies, and, more recently, generative healthcare [14A]. This intersection of bio-mimicry and nanotechnology is paving the way for innovations that blend efficiency, sustainability, and unparalleled effectiveness [11A].
At the nanoscale, materials exhibit unique properties that make them remarkably effective for therapeutic applications. Their increased reactivity enables enhanced bioavailability and targeted action, but these same qualities require careful control to ensure safety. This balance is achieved through advanced particle characterization and encapsulation methods. For example, Aloe-Encapsulated Silver Nanoparticles (AgNPs@AV) leverage plant-based barriers to stabilize particles, reduce toxicity, and prevent interactions with healthy cells, creating a safe and biocompatible therapeutic platform [64].
Nanoparticles achieve superior therapeutic effects with smaller doses compared to bulk materials, minimizing systemic toxicity [65]. However, their effectiveness and safety hinge on precise control of physical properties such as particle size, charge, shape, and aggregation behavior. Proper characterization ensures that nanoparticles function as intended while mitigating potential risks [66].
Colloidal Silver demonstrates how nanoscale properties influence outcomes. Ultrathin particles with defined characteristics, when properly harnessed, deliver enhanced stability, bioavailability, and therapeutic action. Below, we explore the key physical properties of nanoparticles that govern their safety and effectiveness:
The size of nanoparticles and their distribution within a solution are critical factors in determining therapeutic potential. Uniformly small particles are essential for predictable bioavailability and effectiveness. Generally, smaller particles penetrate biological barriers more easily, enhancing their ability to target pathogens and deliver therapeutic benefits [67]. Therapeutic success also relies on the uniformity of particle distribution, as even the smallest particles can lose stability if their sizes are inconsistent within a solution, leading to amalgamation and reduced performance [68].
Distribution, measured as the polydispersity index (PDI), reflects the uniformity of particle sizes in a sample. A low PDI indicates a narrow size range, which ensures consistent performance and minimizes the risk of aggregation or sedimentation [69]. Proper control over particle size and distribution not only improves efficacy but also sets high-quality colloidal silver products apart from less refined alternatives [67][68].
One of the most remarkable characteristics of nanoparticles is their surface area. Subdividing a material into smaller particles significantly increases surface area while maintaining the same overall volume. For colloidal silver, smaller particles translate to higher reactivity and catalytic activity, making the solution more potent while using less material [70].
This property underpins the effectiveness and safety of colloidal silver. Higher surface area allows for more interaction with the surrounding environment, amplifying catalytic activity and enabling superior therapeutic performance. As the surface area-to-volume ratio increases, more of the substance interacts with the surrounding environment, resulting in better catalytic action. This increased efficiency reduces the quantity of silver required for therapeutic effects, minimizing toxicity and enhancing the safety profile of colloidal silver [70][71][72].
In practical applications, particle size determines accessibility, while surface area determines efficiency. Both are critical in ensuring the safety and effectiveness of nanoparticles in therapeutic contexts.
Zeta potential measures the net electric charge at the interface between nanoparticles and their surrounding medium, playing a critical role in colloidal stability and interactions [70]. It provides insight into electrostatic repulsion between particles; higher absolute values indicate stronger repulsive forces, which prevent aggregation and ensure uniform dispersion. This stability helps nanoparticles maintain their nanoscale properties over time, preserving their functionality and effectiveness in solution [71].
Closely tied to zeta potential is surface charge density, which reflects the concentration of electric charge on a nanoparticle’s surface. While zeta potential measures the net effect of surface charges in a colloidal system, surface charge density quantifies the charges themselves. A high surface charge density enhances reactivity, allowing nanoparticles to interact more effectively with microbial membranes or other targets. Together, zeta potential and surface charge density influence not only the stability of the solution but also the bioactivity and therapeutic potential of nanoparticles [72].
In practical applications, controlling zeta potential and surface charge density is essential for optimizing nanoparticle formulations. These parameters ensure stability and enhance the efficacy of nanoparticles, making them invaluable for therapeutic contexts [73].
Nanoencapsulation involves creating protective barriers at the molecular level, utilizing lipid layers or plant-based coatings, that surround individual nanoparticles. These barriers stabilize nanoparticles, prevent aggregation, and enhance bioavailability by facilitating effective interactions with biological systems [74].
Achieving high-quality encapsulation requires meticulous production techniques. Precise control over temperature, the encapsulant’s access to silver nanoparticles, the exact encapsulant-to-particle ratio, timing, light exposure, and other environmental conditions is essential to ensure uniform particle sizes and consistent encapsulation quality. [75]
Plant-based synthesis methods utilize natural extracts as reducing and capping agents, leading to the formation of silver nanoparticles with controlled sizes and shapes. The precision and quality of encapsulation are critical to the safety and efficacy of nanotherapeutics. Proper encapsulation techniques ensure that nanoparticles maintain their desired properties and functionality within biological environments [76][77].
The shape and morphology of nanoparticles significantly influence their behavior and effectiveness in therapeutic applications. While spherical particles are the most common, alternative shapes—such as rods, cubes, or stars—can exhibit unique functional properties. For example, elongated shapes may enhance cellular uptake or increase targeted interactions with pathogens due to their larger surface contact area [78].
In colloidal silver, consistent morphology is as crucial as uniform size distribution. Irregular shapes or inconsistencies in morphology can affect reactivity, bioavailability, and even safety, potentially leading to unpredictable outcomes. Ensuring uniformity in shape and morphology requires advanced production techniques that tightly control synthesis parameters including temperature, precursor concentration, and reaction time. When done effectively, these methods produce nanoparticles with the desired structural integrity, optimizing their therapeutic potential [79].
Aggregation is a critical factor affecting the stability and performance of colloidal silver. When nanoparticles cluster together, their effective surface area decreases, diminishing their therapeutic potential and increasing the risk of sedimentation. Aggregation also impacts bioavailability, as clumped particles are less able to interact effectively with biological targets. Factors influencing aggregation include particle size, zeta potential, encapsulation quality, and environmental conditions such as pH and ionic strength [78].
Preventing aggregation is essential for maintaining the integrity and effectiveness of colloidal silver. Stabilizing agents, high-quality encapsulation techniques, and precise control of production parameters all play a role in minimizing this risk. High-quality colloidal silver solutions are characterized by their resistance to aggregation, which ensures long-term stability and consistent therapeutic performance. Proper monitoring and management of colloidal stability are key to delivering reliable and effective nanoparticle formulations [79].
Nanoparticles interact with light in fascinating ways, creating optical properties that differ dramatically from bulk materials. For colloidal silver, these properties are most evident in its characteristic color, which arises from localized surface plasmon resonance (LSPR). LSPR occurs when nanoparticles resonate with specific wavelengths of light, producing vibrant colors that depend on their size, shape, and dispersion [80].
These optical properties are not just aesthetic; they serve as valuable indicators of particle quality and stability. Changes in color can signify aggregation, shifts in particle size, or degradation of the colloid. For example, a well-dispersed colloidal silver solution at 30 ppm typically exhibits a yellow hue, reflecting the uniformity and nanoscale properties of the particles [81]. In addition to its color, high-quality colloidal silver often exhibits a prismatic clarity or iridescent transparency, giving it a subtle, lustrous sheen that enhances its distinct visual appeal. By understanding and leveraging these optical characteristics, manufacturers can monitor and optimize the quality of colloidal silver solutions throughout the production process.
Crafting aloe-encapsulated colloidal silver requires more than just a basic understanding of chemistry; it demands precision, innovation, and a commitment to safety and efficacy. At Good Electricity, we combine cutting-edge techniques with a bio-mimetic approach inspired by nature, ensuring that every batch meets the highest standards of quality. Our production process is a careful blend of science and artistry, prioritizing sustainability, purity, and the superior therapeutic benefits of encapsulation. This section offers a closer look at the intricate methods behind creating our nano-scale silver solutions, shedding light on what sets our products apart.
The effectiveness of a nano-therapeutic product begins with its core properties—particle size, distribution, and stability. Our proprietary methods ensure that silver nanoparticles are consistently encapsulated with aloe vera, a process that enhances bioavailability while reducing potential toxicity. This dual-layered approach of nano-silver and natural encapsulation creates a product that is safe, potent, and stable over time.
Key to our method is a commitment to precision and control. By leveraging advanced production techniques, we maintain uniformity in particle size and surface chemistry, which directly influence the product’s therapeutic efficacy. This attention to detail elevates our colloidal silver beyond the standard ionic silver solutions commonly found on the market.
Sustainability is woven into every step of our process. From using VOC purified distilled water to ensure purity to harnessing natural reducing agents like aloe vera, we prioritize eco-friendly methods that align with green chemistry principles. Unlike traditional methods that may rely on harsh chemicals or produce waste, our process embodies a commitment to clean, safe, and environmentally conscious production.
By integrating plant-based encapsulation, we not only create a more bioavailable product but also align our methods with nature’s way of reducing and stabilizing nanoparticles. This natural synergy mirrors the gentle yet effective processes found in ecosystems, offering a sustainable alternative to industrial methods.
Encapsulation is the cornerstone of what elevates aloe-encapsulated colloidal silver beyond conventional solutions. By forming a stable, protective layer around each silver nanoparticle, encapsulation ensures structural integrity and prevents agglomeration, which can compromise efficacy. This precise process not only stabilizes the particles but also maintains their uniform distribution, a critical factor in delivering consistent therapeutic benefits.
Beyond stability, encapsulation plays a vital role in enhancing safety. The protective aloe vera coating reduces direct interaction between the nanoparticles and cells, mitigating potential irritation or cytotoxicity. This careful balance allows for the delivery of potent antimicrobial properties while minimizing risks, making aloe-encapsulated colloidal silver both effective and gentle for various applications.
Aloe vera is more than just a plant—it’s nature’s perfect encapsulant. With its rich composition of polysaccharides, vitamins, and antioxidants, aloe vera binds seamlessly with nanoparticles, enhancing their therapeutic potency while reducing potential toxicity. Unlike synthetic stabilizers or other plant-based encapsulants, aloe vera requires less energy to process, making it a sustainable and efficient choice. Beyond structural stability, aloe vera amplifies the bioactive properties of the final product, synergizing with the antimicrobial and healing benefits of silver.
The creation of aloe-encapsulated colloidal silver (AgNPs@AV) exemplifies a conscious blend of science and sustainability. Unlike ionic silver production, which typically relies on straightforward electrolysis, this process incorporates plant-based materials and eco-friendly methods to encapsulate silver nanoparticles. Each step—from selecting aloe vera with stabilizing properties to carefully managing reaction conditions—requires attention to detail and advanced methodology. It’s a deliberate choice to prioritize complexity over convenience, ensuring our products stand out in efficacy and ecological responsibility.
While electrolysis is our primary method, we also recognize the value of alternative production techniques such as co-precipitation. In this process, silver salts are combined with aloe vera and a natural reducing agent, facilitating the formation and encapsulation of nanoparticles.
Co-precipitation is scalable and allows for fine-tuning of particle size and distribution, but it may require additional optimization to achieve the same level of encapsulation efficiency as electrolysis. Both methods align with green chemistry principles, ensuring that our production remains environmentally conscious and sustainable.
Aloe vera serves as a natural nano-factory in our production process, offering multiple benefits:
Reduction: Phytochemicals present in aloe vera act as reducing agents, converting silver ions into nanoparticles without the need for synthetic chemicals.
Stabilization: The polysaccharides and other bioactive compounds in aloe vera stabilize the newly formed nanoparticles, preventing aggregation and ensuring uniformity.
Encapsulation: Aloe vera naturally encapsulates the silver nanoparticles, enhancing their solubility and biocompatibility.
This green synthesis approach aligns with our commitment to environmentally friendly production methods, leveraging the inherent properties of aloe vera to create high-quality colloidal silver.
Achieving optimal therapeutic efficacy with colloidal silver hinges on precise control over its nano-scale properties. The key processes include:
Reduction: This initial step involves converting silver ions into neutral silver nanoparticles. The choice of reducing agents and conditions directly influences the size and distribution of the nanoparticles, which are critical for their biological activity.
Stabilization: Post-reduction, it’s essential to prevent the nanoparticles from aggregating. Stabilizing agents, such as natural polymers or plant extracts, are employed to maintain particle dispersion and ensure long-term stability of the colloidal solution.
Encapsulation: Encapsulating silver nanoparticles with biocompatible materials, like aloe vera, enhances their bioavailability and reduces potential toxicity. This encapsulation not only protects the nanoparticles but also facilitates targeted delivery within biological systems.
By meticulously controlling these processes, we produce colloidal silver with consistent quality, safety, and therapeutic effectiveness.
When it comes to effective Colloidal Silver, careful reduction, stabilization and encapsulation is crucial. Good Electricity uses Aloe Vera cells as the stabilizing agent, which plays a vital role in preventing uncontrollable growth of particles and particle aggregation. (41) Reduction, Stabilization and encapsulation allow for consistent growth rate and particle size, ensuring optimal solubility and biological availability. (42)
Oswald ripening is the process by which particles grow in size through amalgamation, becoming less soluble and biologically available as they do so. By encapsulating colloidal silver within Aloe Vera cells, we can create a product that is both effective and gentle on the body (43). In fact, studies have shown that well-encapsulated Colloidal Silver particles exhibit reduced toxicity compared to unencapsulated or ionic forms (44).
As you hold our Colloidal Silver solution up to the light, you’ll notice it has an amber hue – a sign of its high-quality, well-encapsulated particles. Unlike other products that may appear clear or transparent due to their ionic nature, ours stands out with its distinct coloration. This is because our unique encapsulation process allows for the formation of true colloidal silver particles, which are not simply ions suspended in a solution (45).”
The transformation of silver ions into nanoparticles lies at the heart of colloidal silver production. In our process, aloe vera and light-based methods act as gentle yet effective reducing agents, precisely controlling particle size and shape.
Once formed, the nanoparticles are immediately stabilized by aloe vera, which prevents them from clumping together. This ensures a uniform suspension that maintains its properties over time.
Producing encapsulated aloe colloidal silver requires specialized equipment and rigorous environmental controls. Unlike the relatively simple conditions needed for ionic silver, this process involves careful regulation of temperature, light exposure, and reaction parameters. Such precision ensures the integrity and efficacy of the final product, eliminating inconsistencies common in home or rudimentary manufacturing setups. Our commitment to these high standards underscores our belief that quality is worth the extra effort.
Aloe Vera-specific benefits:
Inductively coupled plasma mass spectrometry (ICP-MS) is a sensitive analytical technique used to identify and quantify the elemental composition of samples, including metals and select nonmetals with atomic masses from 7-250. Samples are analyzed with a Thermo X-Series II ICP-MS equipped with Collision Cell Technology for advanced interference removal
Inductively coupled plasma mass spectrometry (ICP-MS) is a sensitive analytical technique used to identify and quantify the elemental composition of samples, including metals and select nonmetals with atomic masses from 7-250. Samples are analyzed with a Thermo X-Series II ICP-MS equipped with Collision Cell Technology for advanced interference removal.
Transmission Electron Microscopy (TEM) is a technique that uses an electron beam to image a nanoparticle sample, providing much higher resolution than is possible with light-based imaging techniques. TEM is the preferred method to directly measure nanoparticle size, grain size, size distribution, and morphology.
A JEOL 1010 transmission electron microscope is used at an accelerating voltage of 100 keV and an AMT XR41-B 4-megapixel (2048) bottom mount CCD camera. The camera’s finite-conjugate optical coupler provides high resolution and flat focus with less than 0.1% distortion for magnifications as high as 150,000x.
Zeta potential is a measure of the effective electric charge on the nanoparticle surface. The magnitude of the zeta potential provides information about particle stability, with particles with higher magnitude zeta potentials exhibiting increased stability due to a larger electrostatic repulsion between particles.
Zeta potential testing is performed using a Malvern Zetasizer Nano ZS instrument equipped with a HeNe laser operating at 632.8 nm and a scattering detector at 173 degrees.
For centuries, silver has been an integral part of healing practices. Its significance extends beyond its use as a precious metal to preserve food and water [23]. In ancient Greece, Hippocrates (460-370 BCE) recognized the value of silver in treating various ailments [21]. He noted that it possessed antiseptic properties, making it effective for cleaning wounds and preventing infection.
This knowledge was passed down through generations, influencing medical practices in the Middle East and beyond. The Greeks and Romans used silver to treat a range of conditions, from skin issues to eye infections [14]. In Ayurvedic medicine, silver was believed to have antiseptic properties and was employed to address various health concerns.
In ancient Mesopotamia (modern-day Iraq), silver was prized for its ability to purify water and heal wounds [22]. The Babylonians and Assyrians used silver to treat a range of ailments, from skin conditions to eye infections. Similarly, in ancient Egypt, silver was believed to have antiseptic properties and was used to treat various health issues.
The medicinal use of silver continued throughout history. During the Napoleonic Wars, Alexander I of Russia equipped his army with silver-lined casks for water sanitation, a practice that persisted through both World Wars. In the late 19th century, silver’s antibacterial properties were scientifically validated, leading to its application in newborn care and surgical practices.
During World War I, the British government recognized the importance of sanitation in preventing the spread of diseases. As a result, they developed new technologies for purifying water using colloidal silver [15]. This innovation not only improved public health but also laid the groundwork for future research into the antimicrobial properties of silver.
In the mid-20th century, scientists began to study the antimicrobial effects of silver in greater detail. A number of discoveries around the inhibition of bacteria, viruses, and fungi sparked a new wave of interest in its potential as an antibacterial agent [16]. This research led to the development of modern colloidal silver products.
The 20th century saw further advancements. Medical researcher Henry Crookes identified silver’s germicidal properties in colloidal form, and by the 1940s, silver was the primary antibiotic. Research in the 1980s demonstrated its efficacy against over 650 pathogens, further solidifying its place in modern medicine.
The rise of antibiotic-resistant bacteria has made it increasingly difficult to treat certain infections. In response, researchers are turning to natural antimicrobial agents like silver as an alternative or complementary treatment option [17]. Colloidal Silver’s ability to target multiple types of pathogens makes it a valuable addition to any healthcare regimen.
Colloidal Silver has been shown to enhance the efficacy of antibiotics by reducing bacterial resistance and promoting wound healing [18]. By combining silver with traditional antibiotic therapies, doctors can create more effective treatment plans that reduce the risk of resistant bacteria emerging.
In recent years, there has been a resurgence of interest in medicinal silver. As concerns about antibiotic resistance grow, researchers are exploring new ways to harness the antimicrobial properties of silver for human health (19). Our company is at the forefront of this movement, developing innovative products that leverage the power of colloidal silver.
As we look to the future, it’s clear that silver will continue to play a role in helping generate gentle health care soloutions. With its antimicrobial properties and ability to enhance antibiotic efficacy, Colloidal Silver is poised to become an essential tool in the fight against infectious diseases (20). At our company, we’re committed to advancing this technology and making it accessible to people around the world.
From the hum of electrons in the atom to the crackling energy of lightning splitting the sky, life is fundamentally electric. Our planet’s dynamic systems—geological shifts, atmospheric phenomena, and even the rhythmic tides—are driven by intricate energy exchanges. This electric essence forms the foundation of nature’s interconnected systems, reminding us that energy is the thread weaving life and matter together.
Our very existence mirrors the electric dance of the universe. At every scale, from the ionic channels in our cells to the bioelectric pulses in our nerves, electricity orchestrates life. The heart beats with a bioelectric charge, muscles contract with ionic flows, and the brain processes thoughts through cascading electrical impulses. We are truly electric beings, powered by the energy of life itself.
Silver stands out as one of Earth’s most remarkable elements. Its unparalleled conductivity, reflective brilliance, and ability to interact at the nanoscale make it a material of endless potential. Beyond its technical marvels, silver has been a trusted ally in humanity’s journey, supporting health, innovation, and progress for millennia. Its natural synergy with life speaks to its extraordinary versatility and utility.
In a time of rising challenges to health and sustainability, silver is reemerging as a beacon of possibility. Long relied upon for its antimicrobial prowess and therapeutic properties, silver’s resurgence today underscores its potency as a natural, effective solution. As we seek alternatives to synthetic interventions, silver’s timeless benefits are more relevant than ever, offering hope for a healthier, more harmonious future.
On the left is our Stable Ionic Silver formula targeted for topical and respiratory use, and on the right is our Aloe Vera Encapsulated Colloidal Silver immune support formula for internal use. These two are the foundational bases of a large variety of therapeutic products.
WIPO
Silver Nanoparticles as a New Generation of Antimicrobials.
Discusses the synthesis, properties, and broad-spectrum applications of silver nanoparticles, including topical, nebulized, and oral uses.
Rai, M., et al. (2009). Biotechnology Advances.
DOI: 10.1016/j.biotechadv.2008.09.002
Nanosilver: A Nanoproduct in Medical Application.
Reviews silver nanoparticles’ medical uses, including their antimicrobial properties and potential risks.
Chen, X., & Schluesener, H. J. (2008). Toxicology Letters.
DOI: 10.1016/j.toxlet.2008.06.851
Mechanistic aspects of biosynthesized silver nanoparticles against Gram-positive and Gram-negative bacteria.
Demonstrates silver nanoparticles’ effectiveness across bacterial species.
Durán, N., et al. (2016). Nanomedicine.
DOI: 10.1016/j.nano.2016.04.003
Silver in healthcare: Its antimicrobial efficacy and safety in use.
Explores the role of silver in healthcare and its low toxicity profile.
Lansdown, A. B. (2006). Biofunctional Textiles and the Skin.
DOI: 10.1159/000093944
Antiviral action of silver nanoparticles against HIV.
Explains how silver nanoparticles interact with HIV, disrupting viral structures.
Lara, H. H., et al. (2010). Journal of Nanobiotechnology.
DOI: 10.1186/1477-3155-8-1
Antibacterial properties and toxicity from metallic nanoparticles.
Explores the balance between antimicrobial activity and cytotoxicity in metallic nanoparticles, emphasizing the enhanced safety of encapsulated forms.
Vimbela, G. V., et al. (2017). Advanced Drug Delivery Reviews.
DOI: 10.1016/j.addr.2016.11.017
Biosynthesis, Characterization, and Antibacterial Activity of Silver Nanoparticles Derived from Aloe barbadensis Miller Leaf Extract.
Demonstrates the antibacterial activity of Aloe vera-mediated silver nanoparticles and discusses their enhanced stability and bioavailability.
Iranian Journal of Biotechnology. (2020).
DOI: 10.30498/ijb.2020.145075.2383
Differently Environment Stable Bio-Silver Nanoparticles.
Investigates the environmental stability of silver nanoparticles in colloidal form, particularly their resistance to aggregation.
Green Chemistry. (2013).
DOI: 10.1039/C3GC41850H
/ Amending
11A Advances in Nanotechnology Towards Development of Silver Nanoparticle-Based Wound-Healing Agents
This review highlights the multifaceted therapeutic applications of silver nanoparticles, including antimicrobial efficacy, wound healing, and their ability to manage skin infections effectively.
Authors: Zimkhitha B. Nqakala, Nicole R. S. Sibuyi, et al.
Journal: International Journal of Molecular Sciences, 2021, Volume 22, Article 11272.
DOI: 10.3390/ijms222011272
11B Silver Nanoparticles and Their Application in Wound Healing
Describes the role of silver nanoparticles in treating burns and scrapes, with a focus on their rapid action against microbial infections.
Source: Biomaterials, 2015.
DOI: 10.1016/j.biomaterials.2015.01.016
12A Antibacterial Activity of Silver Nanoparticles against Biofilms
This study examines the effectiveness of silver nanoparticles in disrupting bacterial biofilms, a major challenge in chronic infections.
Journal: Critical Reviews in Microbiology, 2017.
DOI: 10.1080/08982104.2017.1288116
12B Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches
This comprehensive review explores the synthesis methods, characterization techniques, properties, and diverse biological applications of silver nanoparticles, highlighting their antibacterial, antifungal, antiviral, and anti-inflammatory activities.
Authors: Shakeel Ahmed, Saif Ali Chaudhry, and Mudasir Ahmad
Journal: International Journal of Molecular Sciences, 2016, Volume 17, Issue 9, Article 1534.
DOI: 10.3390/ijms17091534
Broad-Spectrum Antimicrobial Activity of Nanosilver: A Review (2016).
Reviews the broad-spectrum antibacterial, antifungal, and antiviral properties of nanosilver, with emphasis on its utility against drug-resistant pathogens.
DOI: 10.1002/jat.3201
14 A Nanotechnology-Based Tools to Overcome Antimicrobial Resistance
Discusses how nanotechnology enhances antimicrobial treatments, including the use of silver nanoparticles to combat drug-resistant bacteria and biofilms.
Authors: Mohmmad Younus Wani, Irshad Ahmad Wani, Akhilesh Rai
Source: Chapter in Nanotechnology-Based Strategies for Combating Antimicrobial Resistance, Springer, 2024.
DOI: 10.1007/978-981-97-2023-1_3
14B Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles
Explores the mechanisms by which silver nanoparticles disrupt bacteria, including MRSA, through cell membrane damage and reactive oxygen species generation.
Authors: Satyajyoti Senapati, Ananya Sahu, et al.
Journal: Frontiers in Microbiology, 2016, Volume 7, Article 1831.
DOI: 10.3389/fmicb.2016.01831
15A Silver Nanoparticles as a New Generation of Antimicrobials
This review discusses the broad-spectrum antimicrobial activities of silver nanoparticles, including their effectiveness against Gram-positive and Gram-negative bacteria, as well as various viruses.
Authors: M. Rai, A. Yadav, A. Gade
Journal: Biotechnology Advances, 2009, Volume 27, Issue 1, Pages 76–83.
DOI: 10.1016/j.biotechadv.2008.09.002
15B Mode of Antiviral Action of Silver Nanoparticles Against HIV-1
This study reveals how silver nanoparticles bind to HIV-1’s gp120 glycoprotein, preventing attachment to host cells and inhibiting viral entry and replication.
Authors: Luis M. Elechiguerra, et al.
Journal: Journal of Nanobiotechnology, 2005, Volume 3, Article 6.
DOI: 10.1186/1477-3155-3-6
15 C Silver Nanoparticles for Viral Inhibition: Mechanisms and Applications (2017).
Explains the antiviral mechanisms of silver nanoparticles, focusing on their interaction with viral proteins and replication processes.
Journal of Microbiological Methods.
DOI: 10.1016/j.mimet.2017.03.001
Antifungal Activity and Mode of Action of Silver Nanoparticles on Candida albicans
This study investigates the antifungal effects of silver nanoparticles on Candida albicans, demonstrating their ability to disrupt fungal cell membranes, leading to cell death.
Authors: Keuk-Jun Kim, Woo Sang Sung, Bo Kyoung Suh, Seok-Ki Moon, Jong-Soo Choi, Jong Guk Kim, Dong Gun Lee
Journal: BioMetals, 2009, Volume 22, Pages 235–242.
DOI: 10.1007/s10534-008-9159-2
Silver Nanoantibiotics Display Strong Antifungal Activity Against Multidrug-Resistant Candida auris
This research demonstrates that silver nanoparticles exhibit potent antifungal effects against multidrug-resistant Candida auris, highlighting their potential as effective agents in managing challenging fungal infections.
Authors: Kartikeya T. Rajendran, et al.
Journal: Frontiers in Microbiology, 2020, Volume 11, Article 1673.
DOI: 10.3389/fmicb.2020.01673
Obliteration of Bacterial Growth and Biofilm Through ROS Generation by Ultra-Small AgNPs Synthesized Using a Microbial Method (2017)
Explores the role of green-synthesized silver nanoparticles in breaking down bacterial biofilms and inhibiting bacterial growth through reactive oxygen species (ROS) generation.
Journal: PLOS ONE, 2017, Volume 12, Issue 7, Article e0181363.
DOI: 10.1371/journal.pone.0181363
19A. In Vitro Antimicrobial and In Vivo Wound Healing Effect of Actinobacterially Synthesized Silver, Gold, and Silver–Gold Alloy Nanoparticles
This study evaluates the antimicrobial properties of silver, gold, and silver–gold alloy nanoparticles synthesized using actinobacteria. It demonstrates significant antibacterial activity and enhanced wound healing by promoting collagen deposition and reducing inflammation.
Authors: S. S. Devi, et al.
Journal: RSC Advances, 2017, Volume 7, Pages 1822–1832.
DOI: 10.1039/C7RA08483H
19B. Designing Injectable Dermal Matrix Hydrogel Combined with Silver Nanoparticles for Methicillin-Resistant Staphylococcus aureus Infected Wounds Healing
This study presents a hydrogel dressing with silver nanoparticles that exhibits sustained antibacterial efficacy, reduces inflammation, promotes collagen synthesis, and stimulates angiogenesis, accelerating wound healing in MRSA-infected wounds.
Authors: Sunfang Chen, Jun Yao, Shicheng Huo, et al.
Journal: Nano Convergence, 2024, Volume 11, Article 41.
DOI: 10.1186/s40580-024-00447-0
19C. Green Synthesis of Silver Nanoparticles Using Kenaf Leaves Extract and Their Antibacterial Potential in Acne Management
This study utilizes Hibiscus cannabinus (Kenaf) leaf extract as a natural reducing agent to synthesize silver nanoparticles. The biosynthesized nanoparticles exhibit significant antibacterial activity against acne-causing bacteria, suggesting their potential application in acne treatment.
Authors: Wei Ting Jess Ong, Swee Pin Yeap, Jahurul Haque, Kar Lin Nyam
Journal: Research Square, 2023.
DOI: 10.21203/rs.3.rs-4614655/v1
/Amending
Advances in Nanotechnology for Skin Conditions: Silver Nanoparticles as Therapies (2017).
Focuses on the anti-inflammatory and antimicrobial effects of silver nanoparticles in dermatological applications.
Journal of Pharmaceutical Sciences.
DOI: 10.1002/jps.25185
22A. The Interaction Between Nanoparticles and the Immune System (2017).
Reviews interactions between various nanoparticles, including metallic ones, and the immune system, focusing on their immunomodulatory effects.
Frontiers in Immunology.
DOI: 10.3389/fimmu.2017.00322
22B. Immunomodulatory Effects of Engineered Nanomaterials (2016).
Examines how engineered nanomaterials modulate immune responses, with potential applications in immunotherapy and inflammation control.
Chemical Reviews.
DOI: 10.1021/acs.chemrev.6b00163
23A. Tannic Acid-Modified Silver and Gold Nanoparticles as Novel Stimulators of Dendritic Cells Activation (2018).
Investigates how tannic acid-modified silver nanoparticles stimulate dendritic cell activation, a crucial step in initiating immune responses.
Frontiers in Immunology.
DOI: 10.3389/fimmu.2018.01115
23B. The Impact of Engineered Silver Nanomaterials on the Immune System (2020).
Reviews interactions between silver nanomaterials and the immune system, highlighting their potential to induce pro-inflammatory or anti-inflammatory responses.
Nanomaterials.
DOI: 10.3390/nano10050967
Reactive Oxygen Species and Immune Stimulation by AgNPs (2019).
Shows how silver nanoparticles stimulate immune response by increasing reactive oxygen species, enhancing bacterial death.
Nanomedicine.
DOI: 10.1016/j.nano.2019.03.002
25A. The Interaction Between Nanoparticles and Immune System: Application in Autoimmune Diseases (2022).
Discusses how nanoparticles function as immunomodulators and their potential in treating autoimmune and inflammation-related diseases.
Journal of Nanobiotechnology.
DOI: 10.1186/s12951-022-01343-7
25B. Biomedical Nanomaterials for Immunological Applications: Ongoing Research and Clinical Trials (2020).
Summarizes the current understanding of how nanomaterials interact with the immune system and their potential in immunotherapy.
Nanoscale Advances.
DOI: 10.1039/D0NA00478B
Effect of Silver Nanoparticles on Human Mesenchymal Stem Cell Differentiation
This study investigates the impact of silver nanoparticles on the differentiation of human mesenchymal stem cells (hMSCs). Findings suggest that AgNPs can influence hMSC differentiation, with implications for tissue regeneration.
Authors: M. Greulich, S. Diendorf, T. Simon, et al.
Journal: Beilstein Journal of Nanotechnology, 2014, Volume 5, Pages 2192–2203.
DOI: 10.3762/bjnano.5.214
Nanomaterials Modulate Stem Cell Differentiation: Biological Interaction and Underlying Mechanisms
This review discusses how various nanomaterials, including silver nanoparticles, modulate stem cell differentiation. It highlights biological interactions and mechanisms that support regenerative medicine applications.
Authors: Y. Zhang, Y. Zhi, X. Cui, et al.
Journal: Journal of Nanobiotechnology, 2017, Volume 15, Article 44.
DOI: 10.1186/s12951-017-0310-5
28A Modulatory Role of Silver Nanoparticles and Mesenchymal Stem Cell-Derived Exosome-Modified Scaffold on Immune Response
This study explores how silver nanoparticles, in combination with mesenchymal stem cell-derived exosomes, can modify scaffolds to influence immune responses and support tissue regeneration.
Authors: M. Hashemi, M. Yousefi, A. Ghaffari, et al.
Journal: Frontiers in Chemistry, 2021, Volume 9, Article 699802.
DOI: 10.3389/fchem.2021.699802
28B. Regeneration of Limbal Stem Cells in the Presence of Silver and Gold Nanoparticles
This study investigates the effects of silver and gold nanoparticles on the regeneration of corneal limbal stem cells, demonstrating their potential to promote tissue repair and restore vision in cases of corneal damage.
Authors: Melinda Turani, Gaspar Banfalvi, Krisztina Kukoricza, Judit Jakim, Istvan Pocsi, Adam Kemeny-Beke, Gabor Nagy
Journal: Journal of Environmental & Analytical Toxicology, 2015, Volume 5, Article 318.
DOI: 10.4172/2161-0525.1000318
28C. Induced Dedifferentiation: A Possible Alternative to Embryonic Stem Cell Transplants
This study explores the concept of induced dedifferentiation, where mature cells revert to a more primitive state, offering a potential alternative to embryonic stem cell transplants in regenerative medicine.
Author: Robert O. Becker
Journal: NeuroRehabilitation, 2002, Volume 17, Pages 23–31.
DOI: 10.3233/NRE-2002-17105
29. Silver Nanoparticles Enhance the Efficacy of Conventional Antibiotics Against Multidrug-Resistant Pathogens
This study highlights the synergistic effect of silver nanoparticles when combined with antibiotics like amoxicillin and clindamycin, improving their effectiveness against MDR pathogens.
Journal: Journal of Antimicrobial Chemotherapy, 2019, Volume 74, Pages 1578–1587.
DOI: 10.1093/jac/dkz117
30. Nanotechnology as a Solution to Antibiotic Resistance
This review discusses the use of AgNPs as alternatives and complements to antibiotics, exploring their role in combating resistance.
Journal: Frontiers in Microbiology, 2016, Volume 7, Article 1831.
DOI: 10.3389/fmicb.2016.01831
31. Antibacterial Activity of Silver Nanoparticles Against Biofilms
This study examines the effectiveness of silver nanoparticles in disrupting bacterial biofilms, a major challenge in chronic infections.
Journal: Critical Reviews in Microbiology, 2017, Volume 43, Issue 5, Pages 573–596.
DOI: 10.1080/08982104.2017.1288116
Silver nanoparticles as a new generation of antimicrobials.
Highlights broad-spectrum activity and resistance-proof mechanisms of silver.
Rai, M., et al. (2009). Biotechnology Advances.
DOI: 10.1016/j.biotechadv.2008.09.002
Mechanistic aspects of biosynthesized silver nanoparticles against Gram-positive and Gram-negative bacteria.
Demonstrates silver nanoparticles’ effectiveness across bacterial species.
Durán, N., et al. (2016). Nanomedicine.
DOI: 10.1016/j.nano.2016.04.003
/Amending
Ångstrom-Scale Silver Particles for Wound Healing Applications (2020).
Demonstrates nanoscale silver’s role in promoting angiogenesis and collagen synthesis.
Biomaterials Science.
DOI: 10.1039/D0BM00748C
Silver in healthcare: Its antimicrobial efficacy and safety in use.
Explores the role of silver in healthcare, highlighting its antimicrobial properties and safety profile.
Lansdown, A. B. (2006). Biofunctional Textiles and the Skin, 33–47.
DOI: 10.1159/000093944
“The medical uses of silver: history, myths and scientific evidence
This study examines the historical applications of silver in medicine, tracing its use from ancient civilizations to modern times. It discusses how various cultures utilized silver for its antimicrobial properties and addresses common myths and scientific evidence surrounding its medical use.
Authors: Serenella Medici, Massimiliano Peana, Valeria M. Nurchi, Maria Antonietta Zoroddu
Journal: Journal of Medicinal Chemistry, 2019, Volume 62, Issue 13, Pages 5923–5943
DOI: 10.1021/acs.jmedchem.8b01439
“Shape- and Size-Controlled Synthesis of Silver Nanoparticles Using Aloe vera Plant Extract and Their Antimicrobial Activity
This research details the biogenic synthesis of silver nanoparticles (AgNPs) using Aloe vera plant extract, achieving controlled shapes and sizes. The study evaluates the antimicrobial efficacy of these AgNPs against various bacterial strains, demonstrating significant antibacterial activity.
Authors: Kaliyaperumal Logaranjan, Anasdass Jaculin Raiza, Subash C. B. Gopinath, Yeng Chen, Kannaiyan Pandian
Journal: Nanoscale Research Letters, 2016, Volume 11, Article 520
DOI: 10.1186/s11671-016-1725-x
40B Green synthesis of silver nanoparticles using Aloe vera extract and their anti-inflammatory activity
This study details the biosynthesis of silver nanoparticles utilizing Aloe vera extract and evaluates their anti-inflammatory effects. The synthesized nanoparticles exhibited significant anti-inflammatory activity in vitro, suggesting potential therapeutic applications.
Authors: Kumar, V., Yadav, S. K., & Singh, A.
Journal: Journal of Nanomedicine & Nanotechnology, 2019, Volume 10, Issue 5
DOI: 10.4172/2157-7439.1000537
Green synthesis of silver nanoparticles via Aloe barbadensis miller leaves: Anticancer, antioxidative, antimicrobial, and photocatalytic properties.
Reviews aloe vera as a stabilizing and reducing agent in silver nanoparticle synthesis.
Ghatage, M. M., et al. (2023). Applied Surface Science Advances, 16, 100426.
DOI: 10.1016/j.apsadv.2023.100426
Highlights wound-healing properties of silver nanoparticles, including their roles in reducing inflammation, promoting angiogenesis, and supporting collagen synthesis.
International Journal of Molecular Sciences, 2013, Volume 14, Pages 4817–4840.
DOI: 10.3390/ijms14034817
/ Amending
Green Synthesis of Silver Nanoparticles in Aloe Vera Plant Extract Prepared by a Hydrothermal Method and Their Synergistic Antibacterial Activity.
Explores the synthesis process using aloe vera and highlights its efficacy in preventing aggregation and enhancing stability.
Tippayawat, P., et al. (2016). PeerJ, 4, e2589.
DOI: 10.7717/peerj.2589
Green Synthesis of Silver Nanoparticles Using Plant Extracts and Their Antimicrobial Activities: A Review of Recent Literature.
Reviews eco-friendly synthesis of silver nanoparticles using plant extracts, highlighting their antimicrobial efficacy and role in enhancing stability and biocompatibility.
RSC Advances, 2021, Volume 11, Pages 2804–2837.
DOI: 10.1039/D0RA09941D
Nanosilver: Its Role in Medicine and Its Potential Impact on Human Health.
A comprehensive review of silver nanoparticles’ therapeutic applications, safety profile, and antimicrobial activity.
Journal of Hazardous Materials, 2020, Volume 389, Article 124617.
DOI: 10.1016/j.jhazmat.2020.124617
Repeated dose (28-day) administration of silver nanoparticles of varied size and coating does not significantly alter the indigenous murine gut microbiome.”
Examines the safety of silver nanoparticles in vivo, demonstrating minimal impact on gut microbiota even at high doses.
Nanotoxicology, 2015, Volume 9, Issue 8, Pages 934–943.
DOI: 10.3109/17435390.2015.1078854
The medical uses of silver: history, myths and scientific evidence.”
Explores silver’s historical applications and scientific evidence for its therapeutic uses.
Journal of Medicinal Chemistry, 2019, Volume 62, Issue 13, Pages 5923–5943.
DOI: 10.1021/acs.jmedchem.8b01439
Silver sulfadiazine: Mechanisms of action and clinical applications.”
Discusses the mechanisms and uses of silver sulfadiazine in burn care and infection prevention.
Drugs.com (Monograph).
Available at: https://www.drugs.com/monograph/silver-sulfadiazine-topical.html
Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends.”
Reviews advancements in silver nanotechnology, emphasizing silver nanoparticles’ role in wound healing and antimicrobial applications.
Paladini, F., & Pollini, M. (2019). Materials, 12(16), Article 2540.
DOI: 10.3390/ma12162540
Reference: “Silver Nanoparticles in Water Purification: Opportunities and Challenges.”
Discusses the potential use of silver nanoparticles in water purification systems, including applications in emergency and military contexts.
SpringerLink Book Chapter, 2017.
DOI: 10.1007/978-3-319-64501-8_13
Nanomaterials for Wound Healing: Scope and Advancement.”
This review discusses the application of nanomaterials, including silver nanoparticles, in wound healing, with a focus on their antimicrobial properties in complex wound environments.
PubMed, 2015.
DOI: 10.1016/j.addr.2015.08.009
Aloe Vera Plant Extract as a Reduction Agent.
This study demonstrates the application of Box-Behnken design to optimize the synthesis of silver nanoparticles using aloe vera, achieving high stability and uniform particle size.
Authors: N. Akgül and H. Özkan.
Journal: Saudi Journal of Biological Sciences, 2020.
DOI: 10.16984/saufenbilder.806916
Biofabrication of Silver Nanoparticles Using Moringa Oleifera Leaf Extract and Their Antimicrobial and Antioxidant Potential.
Highlights the green synthesis of silver nanoparticles using Moringa oleifera leaf extract, showcasing significant antimicrobial and antioxidant properties.
Authors: Y. A. Mohamed et al.
Journal: Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2022.
DOI: 10.1007/s10856-022-06688-y
Green Synthesis and Antibacterial Effects of Aqueous Colloidal Solutions of Silver Nanoparticles Using Camomile Terpenoids as a Combined Reducing and Capping Agent.
Explores the use of chamomile terpenoids in the green synthesis of silver nanoparticles, emphasizing their antibacterial effects and enhanced stability.
Authors: T. Köhler et al.
Journal: Bioprocess and Biosystems Engineering, 2016.
DOI: 10.1007/s00449-016-1599-4
Antioxidant and Antibacterial Properties of Green Synthesized Silver Nanoparticles Using Aqueous Extract of Neem (Azadirachta Indica).
Examines the green synthesis of silver nanoparticles using neem extract, focusing on their dual antioxidant and antibacterial activities.
Authors: S. Suresh and K. Arora.
Journal: Phytomedicine Plus, 2020.
DOI: 10.1016/j.phytol.2020.09.012
Green Synthesis of Silver Nanoparticles with Algae and the Importance of Capping Agents in the Process.
Discusses the role of algae in the green synthesis of silver nanoparticles, highlighting the importance of capping agents for stability and bioactivity.
Authors: P. Khataee et al.
Journal: Bioresources and Bioprocessing, 2021.
DOI: 10.1186/s43141-021-00228-w
Biosynthesis of Turmeric Silver Nanoparticles: Its Characterization and Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial Potential Against Oral Pathogens an In Vitro Study.
Describes the synthesis and characterization of silver nanoparticles using turmeric extract, emphasizing their antioxidant, anti-inflammatory, and antimicrobial effects.
Authors: A. Sharma et al.
Journal: Journal of Indian Academy of Oral Medicine and Radiology, 2022.
DOI: 10.4103/jiaomr.jiaomr_309_22
Peeling in Biological and Bioinspired Adhesive Systems.
This study examines the nanoscale adhesive properties of spider silk, highlighting its unique reversible adhesion and self-cleaning capabilities.
Journal: JOM (Journal of Materials), 2020.
DOI: 10.1007/s11837-020-04037-3
X-rays Reveal the Photonic Crystals in Butterfly Wings That Create Color.
Explores the photonic crystals within butterfly wings that produce vibrant, iridescent colors due to their nanoscale structures.
Source: Argonne National Laboratory, 2021.
Available at: https://www.anl.gov/article/xrays-reveal-the-photonic-crystals-in-butterfly-wings-that-create-color
Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review.
Explores the relationship between structural parameters of nanoparticles, including size and shape, and their toxicity profiles for biomedical applications.
Authors: Abbasi, R., et al.
Journal: Journal of Nanoparticle Research, 2023, Volume 25, Article 43.
DOI: 10.1007/s11051-023-05690-w
Therapeutic efficacy of nanoparticles and routes of administration.
Discusses the therapeutic potential of nanoparticles and how their physicochemical properties influence routes of administration and effectiveness.
Authors: Chenthamara, D., et al.
Journal: Biomaterials Research, 2019, Volume 23, Article 20.
DOI: 10.1186/s40824-019-0166-x
Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists.
Provides an overview of nanoparticle classification, their physicochemical properties, and their characterization techniques.
Authors: Joudeh, N., & Linke, D.
Journal: Journal of Nanobiotechnology, 2022, Volume 20, Article 262.
DOI: 10.1186/s12951-022-01477-8
Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.
This review highlights the significance of size and PDI in the successful design, formulation, and development of nanosystems for pharmaceutical applications.
Authors: Danaei, M., et al.
Journal: Pharmaceutics, 2018, 10(2), 57.
DOI: 10.3390/pharmaceutics10020057
A Deep Dive into Lipid Nanoparticle Size Distribution.
Discusses the importance of nanoparticle size distribution and its impact on performance, emphasizing that a PDI lower than 0.3 ensures a consistent and uniform size.
Source: Diversa Technologies, 2024.
Available at: https://www.diversatechnologies.com/lipid-nanoparticle-size-distribution/
Current Analytical Approaches for Characterizing Nanoparticle Sizes in Pharmaceutical Applications.
Examines methods for evaluating nanoparticle size and distribution, highlighting the importance of PDI in quality control.
Authors: Naito, M., et al.
Journal: Journal of Nanoparticle Research, 2023, 25(11), 59.
DOI: 10.1007/s11051-023-05924-x
Silver Nanoparticles in Therapeutics and Beyond: A Review of Biomedical Applications and Toxicology.
This review discusses the unique physicochemical properties of silver nanoparticles, including their high surface-area-to-volume ratio, and their implications for various biological applications.
Authors: Singh, P., et al.
Journal: Nanomaterials, 2024, 14(20), 1618.
DOI: 10.3390/nano14201618
Silver nanoparticles with different size and shape: equal cytotoxicity, different antibacterial activity.
This study examines how the size and shape of silver nanoparticles affect their antibacterial activity and cytotoxicity, highlighting the role of surface area in their effectiveness.
Authors: Pal, S., et al.
Journal: RSC Advances, 2016, 6, 20685-20696.
DOI: 10.1039/C5RA27836H
Nanocatalysis: recent progress, mechanistic insights, and diverse applications.
This article explores the advancements in nanocatalysis, focusing on how increased surface area enhances catalytic activity and its applications in various fields.
Authors: Modi, A., et al.
Journal: Journal of Nanoparticle Research, 2024, 26(1), 53.
DOI: 10.1007/s11051-024-06053-9
Silver Nanoparticles in Therapeutics and Beyond: A Review of Biomedical Applications and Toxicology.
Discusses the unique physicochemical properties of silver nanoparticles, including their high surface-area-to-volume ratio, and their implications for various biological applications.
Authors: Singh, P., et al.
Journal: Nanomaterials, 2024, 14(20), 1618.
DOI: 10.3390/nano14201618
Plant-Mediated Synthesis of Silver Nanoparticles: Their Characteristic Properties and Therapeutic Applications.
Explores the use of plant-based methods in silver nanoparticle synthesis, highlighting their stabilizing and therapeutic properties.
Authors: Chung, I.-M., et al.
Journal: Nanoscale Research Letters, 2016, 11(1), 40.
DOI: 10.1186/s11671-016-1257-4
Plant-Based Fabrication of Silver Nanoparticles and Their Application.
Discusses the role of plant-derived materials in nanoparticle synthesis, focusing on methods, applications, and optimization.
Authors: Mishra, V. K., et al.
Book Chapter: Nanomaterials and Plant Potential, Springer, 2019, pp. 135–175.
DOI: 10.1007/978-3-030-05569-1_5
Plant-Based Synthesis of Silver Nanoparticles and Their Applications.
Highlights plant-based synthesis as a sustainable approach to creating biocompatible and effective silver nanoparticles.
Authors: Husen, A., and Siddiqi, K. S.
Book Chapter: Nanotechnology and Plant Sciences, Springer, 2015, pp. 47–76.
DOI: 10.1007/978-3-319-14502-0_13
Silver Nanoparticles: Synthesis, Structure, Properties, and Applications.
Reviews the synthesis and structural properties of silver nanoparticles, with a focus on applications in nanomedicine.
Authors: Abbas, R., et al.
Journal: Nanomaterials, 2024, 14(17), 1425.
DOI: 10.3390/nano14201725
Shape Matters: Impact of Mesoporous Silica Nanoparticle Morphology on Anti-Tumor Therapy.
Investigates how different nanoparticle shapes affect cellular uptake and therapeutic efficacy in cancer treatment.
Authors: Zhang, X., et al.
Journal: Pharmaceutics, 2024, 16(5), 632.
DOI: 10.3390/pharmaceutics16050632
Synthesis Methods for Nanoparticle Morphology Control in Energy Applications.
Discusses techniques for controlling nanoparticle shape during synthesis and their implications for energy applications.
Authors: Smith, J. A., et al.
Book Chapter: Nanotechnology in Energy Applications, Springer, 2021, pp. 45–67.
DOI: 10.1007/978-3-030-92559-8_3